Aromasin (Exemestane) is an aromatase inhibitor that is commonly used in the treatment of hormone receptor-positive breast cancer in postmenopausal women. It is also sometimes utilized in certain off-label applications related to hormone regulation and bodybuilding.
Aromasin (Exemestane) offers several potential benefits and is highly regarded for its effectiveness in managing estrogen-related conditions. Here are some key advantages and uses of Aromasin:
Estrogen Suppression: Exemestane works by blocking the aromatase enzyme, which is responsible for converting androgens into estrogen. By inhibiting this process, Exemestane helps reduce estrogen levels in the body. This can be beneficial for individuals with hormone receptor-positive breast cancer or those seeking to mitigate estrogen-related side effects.
Breast Cancer Treatment: Exemestane is primarily used as an adjuvant treatment for hormone receptor-positive breast cancer in postmenopausal women. It helps prevent the recurrence of breast cancer by lowering estrogen levels, which can stimulate the growth of cancer cells in certain cases.
Estrogen Control in Bodybuilding: In the bodybuilding and fitness community, Aromasin is sometimes used to manage estrogen levels and minimize the side effects associated with anabolic steroid or hormone use. It can help prevent estrogen-related issues such as water retention, gynecomastia, and other estrogenic side effects.
While Exemestane is generally well-tolerated, it may have potential side effects, including but not limited to hot flashes, joint pain, fatigue, and potential bone density loss. Regular monitoring, proper dosing, and professional guidance are important to ensure optimal safety and effectiveness.
Exemestane (Aromasin) The king of anti-estrogens
Exemestane’s half life in the male body is actually very short (~9 hours) and it is quickly eliminated, however, since as soon as it enters your bloodstream it quickly destroys 80-90 of the aromatase enzymes present in your body, it is effective in maintaining significant reductions in estrogen for up to 72 hours after a single 25mg dose. Estrogen levels only begin to rise again after your body has begun to make new aromatase enzymes to replace the ones destroyed by exemestane.
There is a great study on the pharmacokinetics of exemestane in men which found the following:
- 24 hours after one 25mg dose estrogen levels are reduced by 70-80
- 72 hours later estrogen levels are still 40 below baseline even though the drug itself is almost completely eliminated
- 120 hours after initial dose estrogen levels return to baseline (without rebounding)
this means that you can find the timing and dosage that works for you, i’ve seen some guys recommend between 25mg ed and 12.5mg e4d, and you can see why both are effective while providing different levels of estrogen suppression, and it is this flexibility that makes exemestane such a versatile anti-e.