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STEROIDS LIVER CLEANSER: Simepar silymarin
SIMEPAR
SIMEPAR Pharmacological action Combined preparation for treating diseases of the liver and biliary tract. Hepatoprotector. Thestructure of the drug is a complex of vitamins and extract of thefruits thistle.
SIMEPAR Pharmacological action
Combined preparation for treating diseases of the liver and biliary tract. Hepatoprotector. The structure of the drug is a complex of vitamins and extract of the fruits thistle, which contains silymarin - a group of flavonoid compounds fenilhromanovoy structure (including isomers: silibinin, and silidianin silikristin). Silymarin protects hepatocytes from exposure to hepatotoxic agents, prevents destruction of cell membranes. Improves cellular metabolism. Has hepatoprotective effect of acute and chronic intoxication, as well as antioxidant activity due to binding of free radicals in liver tissue. Has membrane-stabilizing activity, stimulates protein synthesis, promotes regeneration of hepatocytes. Vitamins that are part of the preparation, function as coenzymes in various reactions of carbohydrate and protein metabolism. Pharmacokinetics The absorption and distribution simepar After oral administration, silymarin increasingly allocated to the bile, passing the intrahepatic system. Metabolism and Elimination Silibinin is excreted in the urine. Removing silibinina continued for 24 h. The total amount silibinina excreted in bile, is 20-40% of the dose of only 3-7% of the total dose excreted in urine. Metabolites, in particular, sulfate and glucuronide, and conclusions and the bile. Indications - Cirrhosis of the liver. simepar Dosage regimen Adults and children over the age of 12 years, appoint 1 cap. 3 When the long-term use - for 1 cap. 2 Duration of treatment ranged from 1 to 3 months. The capsules should be taken after meals, not liquid, a small amount of water. |